These genes are directly involved in metabolic pathways for hepatic FAs and triacylglycerol (TAG) synthesis, the uptake of circulating FFAs, hepatic FA β-oxidation, and hepatic secretion of VLDL, all of which play a role in the pathophysiology of NAFLD and imply the direct effects of GLP1 on lipid metabolism [50,51]. This evidence concerns the gene GLP1R and metabolic dysfunction-associated steatotic liver disease.