NLRP3 and metabolic dysfunction-associated steatotic liver disease: One study on a mouse-isolated primary Kupffer cell (KC) cell culture model of NAFLD treated with liraglutide demonstrated that liraglutide attenuated the mitochondrial dysfunction and suppressed NLRP3 inflammasome activation in KCs, resulting in a significant reduction of IL-1β and TNF-α expression levels [76].