While GLP-1R silencing had no effect on gene expression in the oleic acid induced-steatosis cells, the effect of exendin-4 on gene expression with scrambled siRNA was reversed by GLP-1R silencing, implying that the GLP-1R presence and direct agonist–receptor interaction is required for GLP1RA antisteatotic effects in hepatic tissue. The gene discussed is GLP1R; the disease is steatosis.