Figure 1 summarizes the cellular and molecular mechanisms underlying these effects, implying a direct role for GLP1-RAs in hepatic tissue, highlighting their potential in patients with NAFLD. These in vitro studies also identified novel potential targets for NAFLD treatment. Aiming to provide a comprehensive review of currently used cell culture models for GLP1RAs in NAFLD treatment research, we have provided Table 1. Here, GCG is linked to metabolic dysfunction-associated steatotic liver disease.