It has been established that GLP-1 improves insulin sensitivity in peripheral tissues [85], while a recent study provided compelling direct and indirect evidence that GLP-1RAs improves insulin resistance and increase the insulin sensitivity of hepatocytes, as well as demonstrating certain advantages of GLP-1RAs over SGLT-2 inhibitors regarding modulating insulin resistance in NAFLD patients [86]. This evidence concerns the gene GLP1R and Insulin resistance.