All of the evidence presented in this section provides a valuable summary of the positive effects of GLP1-RAs on cell culture models of NAFLD, imply their direct hepatic lipid metabolism-modulating properties and synthesizes the most recently elucidated molecular pathways mediating these effects, as well as pointing out other potential as a therapeutic option for the treatment of NAFLD, while also providing recently obtained evidence suggesting the presence of GLP-1Rs on hepatocytes. Here, GLP1R is linked to metabolic dysfunction-associated steatotic liver disease.