ANO1 and colorectal carcinoma: TMEM16A shRNA decreased the expression of phosphorylation of MEK and ERK1/2 but did not affect the total MEK or ERK1/2 expression levels in high-metastatic-potential SW620 cells, and these results indicated that TMEM16A regulated the growth, migration and invasion of metastatic CRC cells through the MEK/ERK signaling pathway.