To firstly investigate whether TMEM211 is also involved in the migration and invasion of colon cancer cells, two colon cancer cells (HCT116 and DLD-1) with higher TMEM211 expression compared to normal colon FHC cells and other colorectal cancer cells (SW620) (Figure S1A) were silenced by siRNA against TMEM211 (Figure 2A). The gene discussed is LHFPL7; the disease is malignant colon neoplasm.