Similar NSCLC-derived exosomes from tumor cells (e.g., A549, H460 and H1299) carry different expression levels of a range of proteins (e.g., epithelial cell adhesion molecule (EpCAM and carcinoembryonic antigen (CEA)), which results in distinct surface phenotypes reflecting the cancer occurrence and progression [7]. The gene discussed is CEACAM5; the disease is neoplasm.