The effervescence in the field of POC devices is manifested in various directions of development, from monitoring heart failure patients at home (e.g., a lateral flow immunoassay (LFIA) for NT-proBNP coupled with a portable reader and with IoT implementation [11]) to non-invasive monitoring tools to be used in emergency service vehicles or emergency (e.g., a transdermal device for the detection of cardiac troponin by attenuated total reflection Fourier transformed infrared spectroscopy (ATR-FTIR) [12]). The gene discussed is NPPB; the disease is heart failure.