Poor survival in MM patients with SPM may be caused by patient-related factors such as advanced age, male sex, race/ethnicity, genetic predisposition, co-morbidities, and disease-related factors (M-protein, immunoglobulin subtype, clonal hematopoiesis, myeloma genetics and immune dysregulation) [3,8]. Here, MYOM2 is linked to plasma cell myeloma.