BECN1 and cancer: In addition, the degradation of p62 is another widely used marker to monitor autophagic activity because p62 directly binds LC3B and is selectively degraded by autophagy [28,29], and Beclin-1 is the main autophagy gene associated with cancer, and it was reported that autophagy might inhibit or promote tumorigenesis by focusing on Beclin-1 [30,31].