The study of an additional set of genes, including ANKRD26, BCORL1, BRAF, CBL, CSF3R, DNMT3A, ETV6, GATA2, JAK2, KIT, KRAS, NRAS, NF1, PHF6, PPM1D, PTPN11, RAD21, SETBP1, TET2 and WT1, is recommended at AML diagnosis, and some of them can also be used for MRD monitoring [3,14]. The gene discussed is CBL; the disease is acute myeloid leukemia.