For many years and still today, qPCR has been the gold-standard technique for monitoring AML patients harboring the fusion genes PML::RARA in APL and RUNX1::RUNX1T1 and CBFB::MYH11 in core-binding factor (CBF) leukemias [41,42,43]. The gene discussed is PML; the disease is acute promyelocytic leukemia.