A large number of studies have demonstrated the involvement of Piezo1‐mediated mechanotransduction in the pathophysiology of aging, brain injury, and neurodegenerative diseases (Chen et al., 2018; Jäntti et al., 2022; Qu et al., 2023; Segel et al., 2019; Wang et al., 2019). Here, PIEZO1 is linked to neurodegenerative disease.