In detail, activation of the Atr‐Chek1 pathway was found to be involved in inhibiting axon regeneration of sensory neurons in a Drosophila model of sensory neuron injury and a mouse model of sciatic neuropathy, whereas osmotic stress‐mediated activation of the Piezo1 pathway and its downstream NO signaling are key factors contributing to the activation of the Atr‐Chek1 pathway (Li et al., 2021). This evidence concerns the gene CHEK1 and sciatic neuropathy.