INPP5D and malaria: Since human malaria models may differ from the murine malaria models, we also used human P.f. 3D7 gDNA and RNA to stimulate THP-1 cells, and found a similar trend of downregulation in the mRNA levels of Ship1 after P.f. 3D7 gDNA or RNA stimulation (Fig. S7E and F), as in the murine models.