To assess whether SHIP1-mediated IRF3 degradation could be potentiated by malaria parasite DNA, we compared the degradation rates of IRF3 between WT and SHIP1 KO cells upon P.y. gDNA stimulation and found that KO of SHIP1 in RAW 264.7 cells decelerated endogenous IRF3 degradation elicited by P.y. gDNA stimulation (Fig. 4E). Here, INPP5D is linked to malaria.