Our data showed that sh-LTBR-1 and sh-LTBR-2 markedly down-regulated LTBR mRNA expression in both HepG2 and HuH7 cells relative to empty vector transfection (P < 0.01; Fig. S1C), indicating the successful knockdown of LTBR in HCC cells. Here, LTBR is linked to hepatocellular carcinoma.