Inaddition, the PP2Ac protein, an inhibitor of Akt on MAMs, shows lessactivity in Alzheimer’s disease upon introduction of thiol disulfidebonds in its catalytic subunit (Foley et al., 2007).Overall, such changes would result in increased formation of MERCs andincreased transfer of Ca2+, lipids and sterols tomitochondria, which is indeed found in patient tissue, but it remainsto be determined whether cysteine PTMs of MERC proteins are behindthese observations (Hedskog et al., 2013;Montesinoset al., 2020). The gene discussed is AKT1; the disease is early-onset autosomal dominant Alzheimer disease.