In the KA-induced rat model of epilepsy, the levels of TRIP8b Ser237 phosphorylation and CaMKIIα activity are reduced after SE induction, which leads to reduced TRIP8b-HCN1 binding, resulting in a disrupted HCN1 gradient from soma to dendrite, and this may be involved in epileptogenesis [58]. The gene discussed is PEX5L; the disease is epilepsy.