HCN1 and epilepsy: Concepcion et al. identified numerous phosphosites of HCN1 in hippocampal tissues from a TLE rat model and in resected human brain tissue containing epileptogenic zones (EZs); some of the changes replicated the altered properties of the Ih current, indicating that HCN1 channel phosphorylation may be of importance in the pathogenesis of epilepsy [62].