In ER‐positive subgroups, similarly, age (p = 0.011, Table S1), histology (p = 0.001), grade (p < 0.001), tumor size (p < 0.001), node status (p < 0.001), PR (p < 0.001), and Ki67 statuses (p < 0.001) were differently distributed among HER2‐0, HER2‐low, and HER2‐positive tumors. This evidence concerns the gene ESR1 and neoplasm.