The TERT promoter mutation has always been considered a parameter that characterizes meningiomas with a high risk of recurrence16, 17, 31, 32 in light of this new classification, this mutation, together with homozygous deletions of CDKN2A/B, is considered as an independent criterion for the diagnosis of grade III meningioma, irrespective of the histological criteria of anaplasia.16, 27, 33. The gene discussed is CDKN2A; the disease is meningioma.