Risks for increasing OIIRR should be viewed with caution, including occlusion, previous trauma, tooth shape, allergy, low bone turnover, and medication like corticosteroids, strontium ranelate, 4-hexylresorcinol and genetic polymorphism of IL-1B, IL-1RN, RANK, osteoprotegerin, and vitamin D receptor TaqI polymorphisms. This evidence concerns the gene IL1RN and allergic disease.