The top 10 dysregulated pathways were the hypoxia-inducible factor-1 (HIF-1) signaling pathway, glycolysis/gluconeogenesis, central carbon metabolism in cancer, axon guidance, pentose phosphate pathway, fructose and mannose metabolism, bladder cancer, viral life cycle-HIV-1, platinum drug resistance, and biosynthesis of amino acids (Fig. 8D). The gene discussed is HIF1A; the disease is cancer.