It is noteworthy that exosomal circRNA cSERPINE2 in BC cells can cause high IL-6 secretion in TAM through the MALT1-NF-κB-IL-6 axis, while increased IL-6 could positively feedback to enhance ELF4A3 and CCL2 levels to promote cSERPINE2 synthesis and recruitment of TAMs [37]. Here, IL6 is linked to breast cancer.