To the best of our knowledge, there are no studies in the literature reporting a correlation of the effects of epigenetic changes on the expression of miRNAs 126, 305, and 217 and on the frequency of SNPs of genes encoding inflammatory molecules, such as IL-6 and TNF-alpha, and proangiogenic molecules, such as ENOS, VEGF and HIF-1alpha, with endothelial dysfunction, assessed noninvasively by RH-PAT, or with serum levels of inflammatory molecules and adipokines in patients with diabetes with and without lower limb ulcers. This evidence concerns the gene NOS3 and diabetes mellitus.