CD8A and neoplasm: Such modifications in the innate immune cell subsets, were associated with a significant increase in cytotoxic CD8 T cell infiltration with an activated phenotype, as shown by the expression of markers such as ki67, PD-1, T-bet and granzyme B. Unlike macrophage conversion, their depletion with clodronate does not affect CD8 T cell infiltration and activation and does not inhibit OS tumor growth, suggesting that it is better to reprogram the myeloid compartment rather than depleting macrophages “tout court” from the TME.