The comparison of the treated with the contralateral, untreated, lesion within the same mice clearly showed that in mice receiving SD101, TCR clones activated and expanded in the treated tumors, were also present in the untreated lesion, suggesting that tumor-specific CD8 T cell clones can likely home to the draining lymph nodes and then recirculate reaching the secondary tumor site (Fig. 5C, D). This evidence concerns the gene CD8A and neoplasm.