Such modifications in the innate immune cell subsets, were associated with a significant increase in cytotoxic CD8 T cell infiltration with an activated phenotype, as shown by the expression of markers such as ki67, PD-1, T-bet and granzyme B. Unlike macrophage conversion, their depletion with clodronate does not affect CD8 T cell infiltration and activation and does not inhibit OS tumor growth, suggesting that it is better to reprogram the myeloid compartment rather than depleting macrophages “tout court” from the TME. Here, GZMB is linked to neoplasm.