Tinnes et al. proved that epileptic conditions strongly induce TIMP1 synthesis in the hippocampus, which in turn blocks MMP activity to protect the BBB, prevent inflammatory cytokine overflow, and weaken epilepsy, indicating the protective effect of TIMP1, which is consistent with the results of our study that the expression of TIMP1 was decreased in epileptic patients and mice [40]. This evidence concerns the gene TIMP1 and epilepsy.