Based on differential expression, random forest (RF), support vector machine (SVM), nomogram, subtype classification, enrichment, protein‒protein interaction (PPI), immune cell infiltration, and immune function analyses, we identified inhibitor of metalloproteinase-1 (TIMP1) as the most significant IRG associated with temporal lobe epilepsy (TLE). The gene discussed is TIMP1; the disease is temporal lobe epilepsy.