In addition, ApoE-mimetic peptide can also serve as the ligand of triggering receptor expressed on myeloid cells 2 (TREM2), and as a result, the activation of TREM2 can improve neurological functions and attenuate neuroinflammation as well as neuronal apoptosis in the mouse model of intracerebral hemorrhage [46]. The gene discussed is TREM2; the disease is intracerebral hemorrhage.