Anti-inflammatory agents such as corticosteroids, NSAIDs, monoclonal antibodies against as IL-6 (Tocilizumab), IL-1 (Canakinumab), and TNF-α (Adalimumab and Golimumab), and Interferon-based immunotherapy can be applied to treat COVID-19 patients [52–56]. The gene discussed is TNF; the disease is COVID-19.