AKT1 and nasopharyngeal carcinoma: Mechanistically, FAM225A functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target integrin β3 (ITGB3), finally activation of focal adhesion kinase (FAK)/phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT/PKB) signaling to promote nasopharyngeal carcinoma cells proliferation and invasion [16].