ZCCHC4 and hepatocellular carcinoma: In detail, ZCCHC4, one of latest identified m6A methyltransferases which primarily methylates human 28S rRNA and also interacts with a subset of mRNAs, was found to be inhibited DNA damage-induced apoptosis in hepatocellular carcinoma cells by interacting with LncRNA AL133467.2 Further exploring data revealed that knockout of ZCCHC4 promotes AL133467.2 and γH2AX interaction for enhancing chemosensitivity in hepatocellular carcinoma cells [41].