Regarding the mechanisms, LncRNA HCP5 was able to directly interact with YTHDF1, thereby strengthening the binding of YTHDF1 to HK2 mRNA in an m6A- dependent manner, leading to enhancing the stability and expression of HK2 mRNA, of which high expression is mainly responsible for carcinogenicity of esophageal squamous cell carcinoma [87]. This evidence concerns the gene YTHDF1 and esophageal squamous cell carcinoma.