In clear cell renal cell carcinoma cells, m6A-modified Lnc-LSG1, which was identified as a target of METTL14 via high-throughput methylated RNA immunoprecipitation sequencing (MeRIP-seq), can directly bind to epithelial splicing regulatory protein 2 (ESRP2) protein and then facilitate ESRP2 ubiquitination, finally resulting in ESRP2 degradation by interaction with YTHDC1 [37]. The gene discussed is ESRP2; the disease is clear cell renal carcinoma.