CCND1 and hepatocellular carcinoma: Results of a previous study using HCC cell lines (Hep3B, HLF, HLE, PLC/PRF/5, and Huh-7) and the hepatoblastoma cell line Huh-6 treated with Sora, revealed that Sora induced the downregulation of cyclin D1 expression, and induced cell cycle suppression and apoptosis [53].