For instance, JAB1 participated in unfolded protein responses by interactions with ER-resident transmembrane kinase-endoribonuclease inositol-requiring enzyme 1 (IRE1) in response to ER stress (Oono et al. 2004), a well-known abnormal phenomena in the context of AD (Uddin et al. 2021). This evidence concerns the gene COPS5 and Alzheimer disease.