Exploiting publicly available databases of human cancer cell lines across multiple solid tumor subtypes (Cancer Cell Line Encyclopedia, CCLE) and cohorts of patients with RCC with pathological and genomic annotations (TCGA; Tracking renal cancer evolution through therapy, TRACERx; Memorial Sloan Kettering Metastasis, MSK-Met), we confirmed a significant association between IFNR cluster loss and aneuploidy, leveraging metrics of aneuploidy score as WGD and fCNA genome. The gene discussed is IFNAR2; the disease is cancer.