We identified that a significant proportion of the hypomethylated transcripts were bound by YTHDF2 (Fig. 3e), and the half-life of YTHDF2 mRNA targets were significantly increased in the C9ORF72-ALS/FTD iPSNs compared to the control (Extended Data Fig. 6d). This evidence concerns the gene YTHDF2 and frontotemporal dementia.