In C9ORF72-ALS/FTD, the hypomethylation of the repeat-containing intronic RNA (Extended Data Fig. 7a,9a) and the reduction of YTHDC1 protein (Extended Data Fig. 9b,c) could synergistically decelerate the RNA degradation, contributing to the increased accumulation of repeat RNA and DPRs with various toxicity. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.