PTPN2 and diabetes mellitus: Additionally, we previously conducted an analysis among a large subset of our studies (26,017 cases and 20,692 controls) evaluating interactions between genetic predicted gene-expression levels and diabetes on colorectal cancer risk, and identified a statistically significant interaction between genetically predicted gene expression levels for PTPN2 and diabetes (P-value: 2.31 × 10−5) [57].