However, the variant rs9526201 in the LRCH1 gene is associated with pronounced enhancer activity in colon tumor and cancer cell lines (Supplementary Fig. S6B) and is in proximity with several variants that are located in open chromatin, suggesting enhancer activity in normal colon tissues, colorectal cancer cell lines, and several tissues (Supplementary Table S7). The gene discussed is LRCH1; the disease is cancer.