joint test, we identified that the association between diabetes and colorectal cancer risk is modified by a locus on chromosome 13q14.13 within the LRCH1 gene, with genetic variant rs9526201 showing the most significant effect (p-value: 7.84 × 10−09, Supplementary Figs. S3B and S4B, Table 2). The gene discussed is LRCH1; the disease is colorectal cancer.