PPARG and type 2 diabetes mellitus: That study found a statistically significant interaction of T2D with an intronic variant rs4402960 located at the IGF2BP2 gene (interaction P-value: 0.040) and a missense variant rs1801282 at the PPARG gene (interaction P-value: 0.036) The respective p-values for interaction for rs4402960 and rs1801282 with diabetes on colorectal cancer were not nominally significant in our GxE analysis providing limited support for those previously observed interactions.