FMR1 and autism: The ASD-like changes found in mutant juveniles included negative enrichments for ASD-risk gene sets such as SFARI (all and high-confidence) [28], FMRP targets [31, 32], De Novo Missense (protein-disrupting or missense rare de novo variants) [31, 33], and AutismKB (Autism KnowledgeBase) [34, 35], which tend to be downregulated by various ASD-related mutations (Fig. 3c and Supplementary Table 4).