The results showed that the levels of P-IkBα, nuclear P-p65, pSREBP1c, nSREBP1c, FAS, ACC1, and SCD1 in the liver were increased in myeloid cell-specific KO NAFLD mice compared to WT NAFLD mice (Fig. 5A, P < 0.01), while the expression of these proteins in the liver was significantly reduced in MYDGF-replenished mice compared to AAV-GFP mice (Fig. 5B, P < 0.01). The gene discussed is FAS; the disease is metabolic dysfunction-associated steatotic liver disease.