INS and metabolic syndrome: In accordance with our previous study [11], the data also indicated that, compared to WT mice, KO mice showed decreased glucose and insulin tolerance (Fig. S3A–D, Table S4, P < 0.001), developed more severe dyslipidemia (including higher TG, TC, and FFA levels) (Table S4, P < 0.01), and exhibited increased body weight gain (Fig. S3E, F, P < 0.001), but showed no significant differences in food intake, fecal output, fecal lipid content, or blood pressure (Table S4, P > 0.05).