GSEA analysis in both TCGA ESCC and GSE21293 datasets showed that TRIM29 expression negatively correlated with the signature of “HALLMARK IL6-JAK-STAT3 SIGNALING” (Table S3 and Fig. 8A, B), which is often hyperactive in ESCC [41]. This evidence concerns the gene STAT3 and esophageal squamous cell carcinoma.