Furthermore, the expression of PCNA and MKI67 (Ki-67), two markers of mitosis, negatively correlated with TRIM29 at both mRNA and protein levels in TCGA ESCC, GSE21293, and Liu2021 datasets, while the mRNA level of CDKN1A, a cell cycle inhibitory gene, positively correlated with TRIM29 mRNA level in TCGA ESCC and GSE21293 (Fig. 5E–G). Here, CDKN1A is linked to esophageal squamous cell carcinoma.