These findings are surprising given the coexpression of Sst and Oprm1 mRNAs in regions involved in mediating respiratory depression by opioid drugs and the importance of somatostatin-expressing cells in the modulation of breathing (Tan et al., 2008; Cui et al., 2016; de Sousa Abreu et al., 2022). This evidence concerns the gene SST and Respiratory insufficiency due to muscle weakness.