These findings are surprising given the coexpression of Sst and Oprm1 mRNAs in regions involved in mediating respiratory depression by opioid drugs and the importance of somatostatin-expressing cells in the modulation of breathing (Tan et al., 2008; Cui et al., 2016; de Sousa Abreu et al., 2022). The gene discussed is OPRM1; the disease is respiratory depression.