Interestingly, we and others identify that in the adaptive response to compression of cancer cells, PI3K/AKT activation leads either to cell proliferation, survival or to migration (Kalli et al, 2019a; Nam et al, 2019; Di-Luoffo et al, 2023Preprint), that is either pro-tumoral or pro-migratory. The gene discussed is AKT1; the disease is cancer.