GRHL2 loss of function is associated with sensorineural deafness and ectodermal dysplasia (46), the latter of which co-occurs with CL/P in the spectrum of ectrodactyly-ectodermal dysplasia-Cleft Lip/Palate (EEC syndrome) and ankyloblepharon ectodermal defects-cleft lip or palate (AEC syndrome; encompassing Hay–Wells and Rapp–Hodgkin syndromes) (66). Here, GRHL2 is linked to EEC syndrome.