Similarly, in the current study we found that cleft palate can occur among Grhl2Axd/+; Grhl3+/TgGrhl3 fetuses (one out of two) and Grhl3TgGrhl3/TgGrhl3 over-expressing fetuses (one out of four) at E15.5, showing that increased Grhl2 is unlikely to cause CL/P via suppression of GRHL3. This evidence concerns the gene GRHL2 and cleft palate.