WDR45 and neurodegeneration with brain iron accumulation 5: For example, mutations in WDR45, which encodes WIPI4, cause β-propeller protein-associated neurodegeneration (BPAN, formally called static encephalopathy of childhood with neurodegeneration in adulthood [SENDA], OMIM#300894), which is typically characterized by static neurodevelopmental symptoms in the early stage of the disease and neurodegeneration in the late stage of the disease (33–35).