Among the transcription factors that activate the LDLR gene promoter, it has been reported that AMPK activation suppresses the SREBP‐2 and Sp1 activity [29, 30]; however, it stimulates the Egr1 and C/EBPβ activity by increasing their expression levels in hepatoma cells [20, 21]. This evidence concerns the gene SREBF2 and hepatocellular carcinoma.