Loss of gene locus and point mutations in human FOXF1 have been described in patients with Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a rare congenital disorder resulting in decreased alveolar capillary density, abnormal positioning of pulmonary veins, and respiratory insufficiency in infants after birth (Bishop et al., 2011; Towe et al., 2018). Here, FOXF1 is linked to alveolar capillary dysplasia with misalignment of pulmonary veins.