MCU and cancer: Other studies implicate MCU-dependent clearance of cytoplasmic Ca2+ and Ca2+-sensitive CamKII activation in the regulation of cancer cell proliferation (Koval et al., 2019; Zhao and Pan, 2021), as well as inactivation and nuclear-translocation of the transcription factor NFAT (Kim and Usachev, 2009) implicated in cell survival, angiogenesis, and invasion (Qin et al., 2014).