CD274 and gastric cancer: However, the efficacy and safety of combination therapy using PD-1/PD-L1 inhibitors and chemotherapy in patients with advanced GC/GEJC remains controversial.Our meta-analysis investigated the efficacy and safety of anti-PD-1 with chemotherapy in the first-line treatment of advanced GC/GEJC, and to probe the differences in treatment efficacy among PD-L1 expression differences.