This study showed significant differences in IL-18 levels between the intervention groups, namely between the control group and the PUJO group on the day 4th, the sham surgery group and the PUJO group on the day 4th, the PUJO group on the day 4th with PUJO group on the day 7th, and PUJO group day 7th with day 14th. This evidence concerns the gene IL18 and bilateral multicystic dysplastic kidney.