The results of the Mann–Whitney test showed that there was a significant difference in IL-18 levels between the control group and the PUJO group on the day 4th (P=0.028), the Sham surgery group and the PUJO group on the day 4th (P=0.014), the PUJO group on the day 4th and the PUJO group on the day 4th. This evidence concerns the gene IL18 and bilateral multicystic dysplastic kidney.