It plays an important role in mitochondrial protein import machinery in the inner mitochondrial membrane and has been reported to play an important role in cardiomyopathy (Al Tuwaijri et al., 2022; Wachoski-Dark et al., 2022); in non-small-cell lung cancer, DNAJC19 was demonstrated to promote tumor cell growth and metastasis by regulating PI3K/AKT signaling (Zhou et al., 2021). Here, AKT1 is linked to cardiomyopathy.