COG8 and dermatomyositis: Moreover, we found that high LMRGs score correlated with low infiltration of effector immune cells and low immune cell function (Figures 9, 10), which was in accordance with other studies that showed lactate plays a key role in constructing the immunosuppressive microenvironment of PDAC (Husain et al., 2013; de la Cruz-Lopez et al., 2019), and it has been previously indicated that SLC19A3 or COG8 was highly associated with immune infiltration in PDAC or dermatomyositis (Huang et al., 2022; Meng et al., 2022)