Through model construction and internal verification using the TCGA database, TSPYL5, PARVG, KCNJ15, RTN1, CTSW, HMOX1, DCAF12L1, VNN2, and ANXA1 were identified as prognostic genes for UCEC within the shared DEGs of UCEC and PCOS. The gene discussed is RTN1; the disease is polycystic ovary syndrome.