In summary, this study successfully developed and validated a potential marker model for UCEC and PCOS, which identified TSPYL5, PARVG, KCNJ15, RTN1, CTSW, HMOX1, DCAF12L1, VNN2, and ANXA1 as prognostic genes for UCEC. The gene discussed is CTSW; the disease is polycystic ovary syndrome.