However, we must note that mammaglobin and GCDFP15 expression is reduced in high-grade and metastatic tumors (Bhargava and Dabbs, 2011; Chivukula and Dabbs, 2011; Willys and Nazaretian, 2013; Darb-Esfahani et al., 2014). Here, PIP is linked to metastatic neoplasm.