MEGF10 and Alzheimer disease: More recent studies showed that astrocyte-based expression of phagocytic receptors such as C-mer proto-oncogene tyrosine kinase (MERTK) and multiple epidermal growth factor-like domains protein 10 (MEGF10) are down-regulated in AD, resulting in an increase in neuronal damage in one-year-old APP751sl mice (Sanchez-Mico et al., 2021).