TARDBP and amyotrophic lateral sclerosis: It has been reported that mislocalization and aggregation of TAR DNA-binding protein-43 (also known as TAR DNA binding protein; TARDBP/TDP43) from the nucleus to the cytoplasm of neural cells (both neurons and glia) correlates with the loss of synapses in ALS, suggesting a key role for tripartite synapses in the neurodegenerative process (Henstridge et al., 2018).