A recent study showed that synchronized activity of NMDA-Rs and T-type voltage-sensitive calcium channels (T-VSCCs/CACNA1G, CACNA1H, CACNA1I, also known as CaV3.1, CaV3.2, and CaV3.3, respectively) caused rapid bursts of neuronal firing in the lateral brain habenula (LHb), which led to depression-like symptoms in rats (Yang et al., 2018). Here, CACNA1I is linked to major depressive disorder.