NR1H2 and Anxiety: Yang et al. (2018) also observed that locally blocking the NMDA-R or T-VSCCs in the LHb elicited rapid antidepressant effects. Using the conditional Cre recombinase/locus of x-over, P1 (Cre-loxP) system to precisely remove nuclear receptor subfamily 1 group H member 2 (NR1H2/LXRBB) from astrocytes (Li et al., 2021), it was shown that NR1H2/LXRB deletion caused anxiety-like, but not depressive-like, behavior in mice (Li et al., 2021; Lee et al., 2022), thus ruling out the involvement of NR1H2 / LXRB in depressive behavior.