Pyramidal neurons in layer V of the medial prefrontal cortex (mPFC) are primarily involved in mood behaviors, where astrocytic NR1H2 (LXRBB) is critical for synaptic transmission and thus is a potential therapeutic target for the treatment of mood disorders and anxiety-like behavior (Li et al., 2021; Lee et al., 2022). Here, NR1H2 is linked to Anxiety.