In the future, we will use mediated Mendelian analysis to further explore whether hypertension affects ED through different pathways such as circulating cytokines, sex hormone levels, plasma proteomics, etc. Finally, due to the lack of GWAS data on ED in Asian or African populations, only populations of European ancestry were included in this MR analysis, and our findings may not be applicable to other populations. The gene discussed is PLXNA3; the disease is hypertensive disorder.