Furthermore, co-immobilization of gold nanoparticles with TLR7 ligand derivatives, i.e., synthesis of small molecule TLR7 ligand (1V209) and lipoic acid (TA) via 4-, 7-, 10-trioxa-1,13-tridecanediamine and α-mannan Sugar (1V209-αMan-GNPs: sugar nano-adjuvant) significantly enhanced immune stimulation [17]. In conclusion, TLR7 was a potential tumor biomarker that might help cancer patients during the COVID-19 pandemic by acting as a tumor and COVID-19 biomodulator [14]. This evidence concerns the gene TLR7 and neoplasm.