MSH2 and cancer: As shown in Fig. 7A, in KIRC, LIHC, PAAD, PCPG, PRAD, THYM, and UVM, the expression levels of MLH1, MSH2, MSH6, and PMS2 were positively correlated with TLR7, suggesting that in these tumors, TLR7 can upregulate DNA Mismatch repair-related genes to maintain tumor cell viability. Interestingly, we found that EPCAM was inversely associated with most cancers.