The GG (homozygous dominant genotype) form of the TLR7 single nucleotide polymorphisms (SNP) may be a genetic risk factor for COVID-19 infection, severe disease, and poor clinical outcomes because it is a natural ligand for single-stranded RNA viruses [7]. According to studies, common RNA viruses like SARS-CoV-2, which caused COVID-19, infect the innate immune system by binding to TLRs 3, 7, and 8 [8]. TLR7 and TLR8 were phylogenetically and structurally very similar. The gene discussed is TLR7; the disease is COVID-19.