Exercise mitigates Aβ deposition using the Wnt signaling pathway as a mediator: In several studies, it was found that the Wnt/β-catenin signaling pathway may be associated with the dissolution of Aβ deposition in AD, and activation of Wnt/β-catenin promoted α-secretase hydrolysis of APP (Jia et al., 2019). Here, APP is linked to Alzheimer disease.