GSK3B and Alzheimer disease: In addition, another study found that a single acute exercise session could also have the same effect, but with a time-limited effect, i.e., GSK-3β activity decreased immediately after exercise and then recovered (MacPherson et al., 2015), However, the effects of acute exercise on AD has remained controversial, with some suggesting that the oxidative stress that may be induced after acute exercise may be very detrimental to AD (Jin et al., 2015).