DLG4 and Alzheimer disease: In AD, the neurotoxic effects of Aβ can affect the structural part of the postsynapse, particularly important for PSD-95, leading to inhibition of LTP (a major form of synaptic plasticity reflecting changes in physiological activities such as neuroelectricity in synaptic plasticity) and synaptic dysfunction, causing related changes in learning and memory abilities (Tu et al., 2014).