In short, exercise itself “Exerkines” released by motor stimulation act on three classical signaling pathways, AMPK, Wnt, and PI3K/AKT, or directly at the site of the disease to alleviate neuroinflammation, improve synaptic plasticity, promote neurogenesis, reduce Aβ deposition, decrease abnormal tau protein phosphorylation, maintain BBB stability, and improve autophagy, thereby reversing the effects of neuroinflammation, reduced synaptic plasticity, neuronal apoptosis, decreased memory capacity, and degeneration of higher cognitive abilities caused by AD. This evidence concerns the gene MAPT and Alzheimer disease.