Exercise has been shown to have an effect on the activation of the PI3K/AKT signaling pathway, and exercise is beneficial in increasing the content and activity of PI3K in the hippocampus of AD brain, prompting the activation of Akt at Thr308 and Ser473, and the activated Akt inhibits GSK-3β activity by inhibiting GSK-3β phosphorylation at the Ser9 site, thus achieving the inhibition of abnormal Tau phosphorylation and improve NFT (Fang et al., 2018a). The gene discussed is GSK3B; the disease is Alzheimer disease.