AKT1 and Alzheimer disease: Exercise reduces Aβ deposition mediated by PI3K/AKT: A study confirmed that in AD mice, PI3K/AKT pathway was inhibited and Aβ42 was deposited in large amounts, making the memory ability impaired, while reactivation of PI3K/AKT and inhibition of β-catabolase and γ-catabolase activities not only promoted Aβ clearance but also inhibited Aβ deposition (Um et al., 2011).