DNA methylation array profiled the tumour as "methylation class diffuse astrocytoma, <i>MYB</i> or <i>MYBL1</i>-altered subtype B (infratentorial)" and an in-frame <i>MYB::QKI</i> fusion was identified by RNA sequencing, confirming the diagnosis of angiocentric glioma. Here, MYBL1 is linked to central nervous system cancer.