TNF and osteoarthritis: A role for inflammatory cytokines, such as IL-1β and TNF-α, however, has been hypothesized in OA since the 1980s (Pujol and Loyau, 1987), so that in the English language the historical term “osteoarthrosis” (with the Latin suffix -osis standing for “degenerative process” without inflammation) (Atkinson, 1984) has been replaced by “osteoarthritis” to highlight the inflammatory component (Vincent, 2019a) that is part of the disease pathogenesis.