Consistent with RNA sequencing results, a significant increase in the activities of MDA and CAT, and a decrease in the activities of GSH, SOD, and GSH-Px were found in rat gastric tissue of the gastric ulcers group compared to the vehicle group, while those were inhibited in rat gastric tissue of Shudage-4 treated group compared to the gastric ulcers group (Figure 3(e)). The gene discussed is SOD1; the disease is gastric ulcer.